Guanfacine hydrochloride( Guanfacine )

Catalog No. M13896 CAS No. 29110-48-3

A selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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25MG	70	In Stock
50MG	126	In Stock
100MG	203	In Stock
200MG	311	In Stock
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Biological Information

Product Name

Guanfacine hydrochloride
Note

Research use only, not for human use.
Brief Description

A selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone.
Description

A selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone; a sympatholytic agent used to treat hypertension and attention deficit hyperactivity disorder (ADHD).Hypertension Approved(In Vitro):Guanfacine (hydrochloride) increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level.Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks.(In Vivo):Guanfacine (hydrochloride) enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task.Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC.Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing.
In Vitro

Guanfacine (hydrochloride) increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level.Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks.
In Vivo

Guanfacine (hydrochloride) enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task.Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC.Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing.
Synonyms

Guanfacine
Pathway

GPCR/G Protein
Target

Adrenergic Receptor
Recptor

α2A-adrenoceptor
Research Area

Cardiovascular Disease
Indication

Hypertension

Chemical Information

CAS Number

29110-48-3
Formula Weight

282.5542
Molecular Formula

C9H10Cl3N3O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 30 mg/mL
SMILES

Cl.NC(N)=NC(=O)CC1=C(Cl)C=CC=C1Cl
Chemical Name

Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, hydrochloride (1:1)